This article studies the anesthetic effect and efficiency of alfaxalone /ketamine or alfaxalone /xylazine anesthesia given in 7-10 day-old chicks. The data on the anesthetic properties of alfaxalone in the birds is relatively inadequate. O BJECTIVE, alfaxalone is a neuro-steroidal anesthetic agent. After FMZ injection, a GABAA receptor antagonist blocked the anticonvulsive effect in both the DZP and EEOS groups, suggesting that EEOS exerts it action on the GABAA receptor at the benzodiazepine (BDZ) subunit. In addition, EEOS presented no significant difference in comparison to DZP, which has the same mechanism of action. Electrodes implanted on the dura mater provided EEG data in which EEOS suppressed seizure deflagration caused by PTZ. Male Wistar rats were treated with EEOS (300 mg/kg), diazepam (DZP) (5 mg/kg), pentylenetetrazol (PTZ) (60 mg/kg) and flumazenil (FMZ) (0.1 mg/kg) by intraperitoneal (i.p.). The present study investigated through electroencephalographic (EEG) profiling the anticonvulsant protective properties of EEOS in induced convulsing rats. Our previous study found an anticonvulsant property of an extract of Euterpe oleracea stone (EEOS) that caused myorelaxation, sedation, and cardiac and respiratory depression after intraperitoneal administration. Approximately 80% of all epileptic patients reside in low-income conditions or in developing countries, and over 75% of patients do not receive proper treatment. More than 70 million people suffer seizures caused by neurological abnormalities. This condition can be triggered by birth trauma, traumatic brain injury (TBI), infections of the brain and stroke. Epilepsy is one of the most common neurological diseases globally, resulting from a disorder in brain activity.
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